Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents

Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents

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Solid tumours are often poorly oxygenated, which confers resistance to standard treatment modalities. Targeting hypoxic tumours requires compounds, such as nitroimidazoles (NIs), equipped with the ability to reach and become activated within diffusion limited tumour niches. NIs become selectively en...

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Bibliographic Details
Main Authors: Diaz-Dussan, D. (Author), El-Saidi, H. (Author), Ismail, I.H (Author), Kumar, P. (Author), Macdonald, D. (Author), Mashayekhi, F. (Author), Narain, R. (Author), Nation, P.N (Author), Rashed, F.B (Author), Ricardo, C. (Author), Sokhi, S. (Author), Stoica, A.C (Author), Weinfeld, M. (Author), Wiebe, L.I (Author), Yang, X.-H (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Head and neck tumour
Hypoxia
Nitroimidazole
Replication stress
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