Nanoparticle albumin-bound paclitaxel with cetuximab and carboplatin as first-line therapy for recurrent or metastatic head and neck cancer: A single-arm, multicenter, phase 2 trial

Objectives: Macropinocytosis promotes internalization of albumin into cells to serve as a nutrient supply and is constitutively driven by signaling pathways frequently hyperactivated in head and neck squamous-cell carcinoma (HNSCC). In this way, drugs bound to albumin may selectively target HNSCC. n...

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Bibliographic Details
Main Authors:	Adkins, D. (Author), Atiq, O. (Author), Gitau, M. (Author), Ley, J. (Author), Liu, J. (Author), Oppelt, P. (Author), Palka, K. (Author), Powell, S. (Author), Rigden, C. (Author), Spanos, W.C (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2021
Subjects:	130-nm albumin-bound paclitaxel acne adult aged Aged albuminoid Albumins anemia antineoplastic agent Antineoplastic Combined Chemotherapy Protocols Article aspartate aminotransferase aspartate aminotransferase blood level aspiration body weight disorder body weight loss cancer combination chemotherapy cancer growth cancer immunotherapy cancer patient cancer recurrence cancer survival carboplatin Carboplatin catheter infection cause of death cetuximab Cetuximab cisplatin clinical trial comorbidity coughing creatinine creatinine blood level diarrhea docetaxel dry skin durvalumab dysarthria dysgeusia dyspnea epistaxis fatigue female Female fluorouracil follow up Head and Neck Neoplasms head and neck squamous cell carcinoma Head and neck squamous-cell carcinoma head and neck tumor heart arrest hematuria hoarseness human Humans hypomagnesemia hypotension infusion reaction leukocyte disorder loading drug dose lung infection lymphocyte count lymphocytopenia maintenance chemotherapy major clinical study male Male metastasis Metastatic disease middle aged Middle Aged mitomycin mouth pain multicenter study multiple cycle treatment Nab-paclitaxel nanoparticle Nanoparticles nausea Neoplasm Recurrence, Local neutropenia neutrophil count nivolumab oral mucositis overall survival paclitaxel Paclitaxel pain palbociclib paronychia pathology pembrolizumab peripheral edema peripheral neuropathy phase 2 clinical trial platelet count priority journal progression free survival rash Recurrent disease respiratory failure sensory neuropathy sepsis side effect systemic therapy taxane derivative thrombocyte disorder thromboembolism tracheal hemorrhage trismus tumor pain tumor recurrence upper gastrointestinal bleeding
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Nanoparticle albumin-bound paclitaxel with cetuximab and carboplatin as first-line therapy for recurrent or metastatic head and neck cancer: A single-arm, multicenter, phase 2 trial

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