UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line

UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line

Objectives: Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line....

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Bibliographic Details
Main Authors: Castilho, R.M (Author), Divi, V. (Author), Nör, J.E (Author), Oklejas, A.E (Author), Pearson, A.T (Author), Polverini, P.J (Author), Rodriguez-Ramirez, C. (Author), Warner, K.A (Author), Wu, W. (Author), Zhang, Z. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
adenoid cystic carcinoma
adenoid cystic carcinoma cell line
adult
allele
animal
animal experiment
animal model
Animals
Article
cancer resistance
Carcinoma, Adenoid Cystic
Cell Line, Tumor
cell proliferation
cisplatin
C-Myb
controlled study
cytokeratin
drug screening
Experimental models
Experimental therapeutics
female
Female
gene fusion
Gene fusion
genetics
hepatocyte nuclear factor 1beta
heterozygosity loss
human
human cell
Humans
intron
lung metastasis
lymph node
Mice
Mice, SCID
middle aged
Middle Aged
mouse
mucoepidermoid carcinoma cell line
MYB-NFIB
MYB-NFIB fusion protein, human
nonhuman
Oncogene
oncogene c myb
Oncogene Proteins, Fusion
oncoprotein
Orthotopic
orthotopic transplantation
paclitaxel
Paclitaxel
pathology
pilot study
primary cell culture
Primary Cell Culture
priority journal
procedures
protein Myb
reverse transcription polymerase chain reaction
salivary gland
Salivary gland
Salivary gland cancer
Salivary Gland Neoplasms
salivary gland tumor
Salivary Glands
SCID mouse
short tandem repeat
submandibular gland
tumor cell line
tumor xenograft
uvomorulin
whole exome sequencing
Xenograft Model Antitumor Assays
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