Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database

Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database

Alismatis Rhizoma (AR) is widely used in Chinese medicine, and its major bioactive components, triterpenes, reportedly possess various pharmacological activities. Therefore, it is very important to study the metabolism of triterpenes in vivo. However, the metabolism of AR triterpene extract has not...

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Bibliographic Details
Main Authors: Cheng, Z. (Author), Du, Z. (Author), Feng, Y. (Author), Jiang, H. (Author), Li, J. (Author), Li, S. (Author), Ouyang, H. (Author), Wang, L. (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
11 dehydro 22 hydroxy 24,25 dideoxy alisol a
11 dehydro 24 deoxy alisol a
11 dehydro 25 deoxy alisol a
11,24 dideoxy 16 oxo alisol a
11,24,25 trideoxy 22 hydroxy 16 oxo alisol a
11,25 dideoxy 16 oxo alisol a
13,17 epoxy alisol b
16 oxo alisol a 24 acetate
22 hydroxy 16,23 oxido alisol b
22 hydroxyalisol b
22 oxo 24 deoxy alisol a
22 oxo 25 deoxy alisol a
23 dehydro 16 oxo alisol a
24 oxo alisol a
Alismatis extract
Alismatis rhizoma
alisol b 23 acetate
alisol c 23 acetate
alisol f
animal experiment
Article
bile
blood analysis
chemical analysis
conjugation
controlled study
data base
dehydrogenation
drug identification
drug metabolite
drug transformation
feces analysis
glucuronidation
HPLC-QTOF-MS/MS
hydrogenation
in vivo study
ion
male
metabolic fingerprinting
Metabolites
nonhuman
oxidation kinetics
pharmacodynamics
pharmacokinetic parameters
quadrupole mass spectrometry
rat
sulfate
sulfuric acid
tandem mass spectrometry
tifenamil
time of flight mass spectrometry
triterpene derivative
Triterpenes
ultra performance liquid chromatography
unclassified drug
urinalysis
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