Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure

Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure

Jumonji domain–containing protein-3 (JMJD3), a histone H3 lysine 27 (H3K27) demethylase, promotes endothelial regeneration, but its function in neointimal hyperplasia (NIH) of arteriovenous fistulas (AVFs) has not been explored. In this study, we examined the contribution of endothelial JMJD3 to NIH...

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Bibliographic Details
Main Authors: Chen, C. (Author), Cheng, J. (Author), Feng, S. (Author), Guo, Q. (Author), Huang, F. (Author), Lee, T.H (Author), Li, Q. (Author), Peden, E.K (Author), Yuan, Y. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Alkylation
Amino acids
Arteriovenous fistulas
Cell regeneration
Chronic kidney disease
Demethylase
Domain-containing proteins
Down-regulation
Endothelial cells
Endothelial-cells
Histone H3
Mammals
Methylation
Muscle
Neointima formation
Neointimal hyperplasia
Nitric oxide
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