Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation

Background: Eurycoma longifolia (E. longifolia) has gained remarkable recognition due to its promising efficacy of stimulating bone formation in androgen-deficient osteoporosis. Numerous in vivo studies have explored the effects of E. longifolia on osteoporosis; however, the in vitro cellular mechan...

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Bibliographic Details
Main Authors:	Hussain, Z. (Author), Mohamed, I.N (Author), Shuid, A.N (Author), Thu, H.E (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2019
Subjects:	acid phosphatase tartrate resistant isoenzyme androgen receptor animal cell antioxidant activity Article bone morphogenetic protein 2 bone regeneration Bone resorption cathepsin K cell activation cell differentiation cell maturation cell proliferation cell proliferation assay cell viability collagen type 1 controlled study cytotoxicity down regulation enzyme activity enzyme linked immunosorbent assay Eurycoma longifolia Eurycoma longifolia extract gelatinase B immunoglobulin enhancer binding protein in vitro study lactate dehydrogenase Molecular mechanism mouse nonhuman osteocalcin osteoclast osteoclast differentiation factor osteoclastogenesis Osteoclastogenesis Osteoclasts osteolysis osteopontin Osteoporosis phase contrast microscopy priority journal RAW 264.7 cell line reactive oxygen metabolite superoxide superoxide dismutase transcription factor transcription factor NFATc1 transcription factor RUNX2 transforming growth factor beta1 unclassified drug
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Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation

Internet

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