Identification of the transcription factor, AFF4, as a new target of miR-203 in CNS

MiR-203 was identified as a hub of a potential regulatory miRNA network in central nervous system. Overexpressing of miR-203 in the frontal cortex of C57BL/6J wild type mouse induced neurodegeneration by increasing the apoptotic pathway and neuron death. AFF4, a transcription factor, was identified...

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Bibliographic Details
Main Authors:	Cao, L. (Author), Gan, J. (Author), Li, L. (Author), Li, S. (Author), Liang, X. (Author), Liang, Y. (Author), Zou, Y. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	14-3-3θ AFF4 Aff4 protein, mouse animal animal cell animal experiment animal model animal tissue Animals apoptosis Apoptosis Article behavior assessment cell death central nervous system Central Nervous System Cognition controlled study disease model Disease Models, Animal down regulation drug effect electron microscopy frontal cortex gene expression regulation Gene Expression Regulation gene function gene identification gene overexpression genetics hippocampus Hippocampus human human cell Humans in vitro study in vivo study Maze Learning maze test metabolism Mice microRNA microRNA 203 MicroRNAs miR-203 MIRN203 microRNA, mouse Morris water maze test mouse nerve cell nerve degeneration Neurons nonhuman open field test pathology protein interaction protein targeting RNA binding signal transduction Signal Transduction staining synaptic potential transcription elongation factor transcription factor transcription factor AFF4 Transcriptional Elongation Factors unclassified drug Western blotting Y-maze test
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Identification of the transcription factor, AFF4, as a new target of miR-203 in CNS

Internet

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