The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell function and fate remains elusive. We found that genetic de...

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Bibliographic Details
Main Authors: Donda, A. (Author), Dumauthioz, N. (Author), Franco, F. (Author), Ho, P.-C (Author), Jaccard, A. (Author), Lepez, A. (Author), Lunt, S.Y (Author), Maldonado-Pérez, N. (Author), Martín, F. (Author), Migliorini, D. (Author), Renaud, F. (Author), Romero, P. (Author), Teoh, S.T (Author), Tschumi, B. (Author), Waridel, P. (Author), Wenes, M. (Author), Wyss, T. (Author), Yacoub Maroun, C. (Author), Zhang, L. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
chimeric antigen receptor T cell therapy
immunometabolism
mitochondrial pyruvate carrier
T cell memory
tumor-infiltrating lymphocyte metabolism
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