Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission

Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission

Remdesivir is a novel antiviral drug, which is active against the SARS-CoV-2 virus. Remdesivir is known to accumulate in the brain but it is not clear whether it influences the neurotransmission. Here we report diverse and pronounced effects of remdesivir on transportation and release of excitatory...

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Bibliographic Details
Main Authors: Afonina, U. (Author), Borisova, T. (Author), Dovbeshko, G. (Author), Dudarenko, M. (Author), Gnatyuk, O. (Author), Krisanova, N. (Author), Pastukhov, A. (Author), Pozdnyakova, N. (Author), Pyrshev, K. (Author), Shatursky, O. (Author), Yesylevskyy, S. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Amphiphilicity
Anti-SARS-COV-2 drug
Antiviral drug
Brain nerve terminals
COVID-19
Excitation
Exocytosis
FTIR spectroscopy
Inhibition
Molecular dynamics simulations
Planar phospholipid bilayer membranes
Synaptic neurotransmission
Synaptic vesicle acidification
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