A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera

A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera

Next-generation COVID-19 vaccines are critical due to the ongoing evolution of SARS-CoV-2 virus and rapid waning duration of the neutralizing antibody response against current vaccines. The mRNA vaccines mRNA-1273 and BNT162b2 were developed using linear transcripts encoding the prefusion-stabilized...

Full description

Bibliographic Details
Main Authors: Bhukhai, K. (Author), Buasri, N. (Author), Hongeng, S. (Author), Kuhaudomlarp, S. (Author), Leelukkanaveera, P. (Author), Lerdwattanasombat, P. (Author), Manopwisedjaroen, S. (Author), Olmedillas, E. (Author), Phueakphud, N. (Author), Saphire, E.O (Author), Seephetdee, C. (Author), Thitithanyanont, A. (Author), Wongtrakoongate, P. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
SARS-CoV-2
Spike
Vaccine
VFLIP
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items