Association of loss of heterozygosity and PTEN gene abnormalities with paraclinical, clinical modalities and survival time of glioma patients in Malaysia

Association of loss of heterozygosity and PTEN gene abnormalities with paraclinical, clinical modalities and survival time of glioma patients in Malaysia

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BACKGROUND: The pattern of allelic loss of heterozygosity (LOH) and PTEN mutations appear to be associated with the progression of gliomas leading to a decrement in the survival rate of patients. This present study was carried out to determine the LOH and PTEN mutational status in glioma patients an...

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Bibliographic Details
Main Authors: Abdullah, J.M (Author), Asmarina, K. (Author), Farizan, A. (Author), Ghazali, M.M (Author), Isa, M.N (Author), Jaafar, H. (Author), Naing, N.N (Author), Zainuddin, N. (Author)
Format: Article
Language:English
Published: Elsevier (Singapore) Pte Ltd 2006
Subjects:
adult
article
cancer grading
cancer survival
clinical article
conformation
controlled study
disease course
female
gene mutation
genetic polymorphism
glioma
Gliomas
heterozygosity loss
human
LOH
Malaysia
Malaysian
male
outcome assessment
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
Prognosis
PTEN mutations
Survival
survival time
tumor vascularization
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