Pharmacologically induced N-methyl-D-aspartate receptor hypofunction impairs goal-directed food seeking in rats

Pharmacologically induced N-methyl-D-aspartate receptor hypofunction impairs goal-directed food seeking in rats

Aim: Acute N-methyl-D-aspartate (NMDA) receptor antagonism is an important pharmacological animal model of schizophrenia. In previous studies, schizophrenia patients show impaired goal-directed behavior in an outcome-specific devaluation procedure. In this study, we investigated whether the rat mode...

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Bibliographic Details
Main Authors:	Ichitani, Y. (Author), Itokazu, T. (Author), Ozawa, T. (Author), Yamada, K. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult animal animal experiment Animals Article Conditioning, Operant controlled study devaluation dizocilpine dizocilpine maleate Dizocilpine Maleate drug effect early goal-directed therapy food intake food-seeking behavior Goals human Humans ketamine lipid low drug dose male MK-801 motivation n methyl dextro aspartic acid receptor NMDA receptor nonhuman operant conditioning phencyclidine physiology rat rats Rats Receptors, N-Methyl-D-Aspartate reward Reward satiety response schizophrenia sucrose
Online Access:	View Fulltext in Publisher

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