Pharmacologically induced N-methyl-D-aspartate receptor hypofunction impairs goal-directed food seeking in rats

Pharmacologically induced N-methyl-D-aspartate receptor hypofunction impairs goal-directed food seeking in rats

Aim: Acute N-methyl-D-aspartate (NMDA) receptor antagonism is an important pharmacological animal model of schizophrenia. In previous studies, schizophrenia patients show impaired goal-directed behavior in an outcome-specific devaluation procedure. In this study, we investigated whether the rat mode...

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Bibliographic Details
Main Authors: Ichitani, Y. (Author), Itokazu, T. (Author), Ozawa, T. (Author), Yamada, K. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
animal
animal experiment
Animals
Article
Conditioning, Operant
controlled study
devaluation
dizocilpine
dizocilpine maleate
Dizocilpine Maleate
drug effect
early goal-directed therapy
food intake
food-seeking behavior
Goals
human
Humans
ketamine
lipid
low drug dose
male
MK-801
motivation
n methyl dextro aspartic acid receptor
NMDA receptor
nonhuman
operant conditioning
phencyclidine
physiology
rat
rats
Rats
Receptors, N-Methyl-D-Aspartate
reward
Reward
satiety response
schizophrenia
sucrose
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