Abnormal regulation of microRNAs and related genes in pediatric β-thalassemia

Abnormal regulation of microRNAs and related genes in pediatric β-thalassemia

Background: MicroRNAs (miRNAs) participate in the reactivation of γ-globin expression in β-thalassemia. However, the miRNA transcriptional profiles of pediatric β-thalassemia remain unclear. Accordingly, in this study, we assessed miRNA expression in pediatric patients with β-thalassemia. Methods: D...

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Bibliographic Details
Main Authors: Chen, M. (Author), Huang, H. (Author), Pan, Y. (Author), Wang, H. (Author), Xu, L. (Author), Xu, S. (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
Article
B-cell lymphoma/leukemia 11A
beta thalassemia
beta-Thalassemia
case control study
Case-Control Studies
Child, Preschool
clinical article
controlled study
DNA synthesis
down regulation
female
Female
gene expression profiling
Gene Expression Profiling
gene expression regulation
Gene Expression Regulation
gene regulatory network
Gene Regulatory Networks
gene silencing
genetic transcription
genetics
human
human cell
human serum albumin
Humans
let7 microRNA
male
Male
mean corpuscular hemoglobin
mean corpuscular volume
microRNA
microRNA 106a 5p
microRNA 17 5p
microRNA 20a 5p
microRNA 221 3p
microRNA 329 3p
microRNA 433 3p
microRNA 4435
microRNA 4508
microRNA 483 3p
microRNA 495 3p
microRNA 543
microRNA 6501 5p
microRNA 6747 3p
microRNA 92b 5p
microRNA 93 5p
microRNA let 7a 3p
microRNA let 7f 1 3p
microRNA let 7g 5p
microRNA let 7i 5p
microRNA let7b 5p
microRNA sequencing
MicroRNAs
morphogenesis
pathology
pediatric β-thalassemia
phosphatidylinositol 3 kinase
platelet count
preschool child
prognosis
Prognosis
protein kinase B
RNA isolation
RNA sequence
transcription regulation
transforming growth factor beta
transforming growth factor beta receptor
unclassified drug
upregulation
γ-globin reactivation
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