CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3

CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3

Background: Lung cancer is the most commonly diagnosed cancer and leading cause of cancer death, with 80%–85% of non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) have been shown to be promising early diagnostic and therapeutic molecular biomarkers for NSCLC. However, biological role and...

Full description

Bibliographic Details
Main Authors: Chen, J. (Author), Shen, D. (Author), Shi, F. (Author), Yang, Q. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
AKT3
AKT3 protein, human
apoptosis
Article
bioinformatics
Biomarkers, Tumor
cancer cell
cancer growth
cancer prognosis
cancer tissue
carcinogenesis
Carcinoma, Non-Small-Cell Lung
cell culture
cell function
cell invasion
Cell Line, Tumor
cell migration
cell viability
circular ribonucleic acid
circWHSC1
colony formation
controlled study
down regulation
gain of function mutation
gene expression regulation
Gene Expression Regulation, Neoplastic
gene function
gene overexpression
gene silencing
gene targeting
genetic association
genetic identification
genetic transfection
genetics
human
human cell
human tissue
Humans
in vitro study
loss of function mutation
luciferase assay
Lung Neoplasms
lung tumor
major clinical study
metabolism
metastasis
microRNA
microRNA 296 3p
MicroRNAs
miR-296-3p
MIRN128 microRNA, human
MIRN296 microRNA, human
non small cell lung cancer
non-small cell lung cancer
pathology
prognosis
Prognosis
protein expression
protein kinase B
protein serine threonine kinase
protein serine threonine kinase 3
Proto-Oncogene Proteins c-akt
real time polymerase chain reaction
RNA interference
RNA, Circular
survival analysis
tumor cell line
tumor marker
unclassified drug
upregulation
Up-Regulation
Western blotting
WHSC1 gene
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items