A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese

A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese

Background: Idiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. Hyaluronidase 1 (HYAL1) was found to be upregulated in fibroblasts from IPF patients, and overexpression of HYAL1 could prevent human fetal lung fibroblast proliferation. Howeve...

Full description

Bibliographic Details
Main Authors: Cheng, Z. (Author), Deng, Y. (Author), Fang, S. (Author), Ge, R. (Author), Li, J. (Author), Li, Z. (Author), Liu, J. (Author), Luo, G. (Author), Mo, B. (Author), Peng, Q. (Author), Shu, Y. (Author), Wang, X. (Author), Wang, Y. (Author), Wang, Z. (Author), Wei, G. (Author), Wei, J. (Author), Wu, M. (Author), Xiong, W. (Author), Xu, X. (Author), Yang, H. (Author), Yang, J. (Author), Yang, S. (Author), Zhang, X. (Author), Zhu, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
aged
Aged
Article
Asian
Asians
case control study
Case-Control Studies
Chinese
connective tissue disease
controlled study
disease association
disease predisposition
false positive result
female
Female
fibrosing alveolitis
gene
gene frequency
Gene Frequency
gene sequence
gene targeting
genetic association
genetic code
genetic identification
genetic polymorphism
genetic predisposition
Genetic Predisposition to Disease
genetic risk
genetic variability
genetics
genotype
Han Chinese
human
Humans
HYAL1 gene
HYAL1 protein, human
hyaluronidase 1
hyaluronoglucosaminidase
Hyaluronoglucosaminidase
idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis
interstitial lung disease
Lung Diseases, Interstitial
major clinical study
male
Male
middle aged
Middle Aged
pathogenesis
polymorphism
Polymorphism, Single Nucleotide
population structure
single nucleotide polymorphism
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items