Associations of PER3 polymorphisms with clopidogrel resistance among Chinese Han people treated with clopidogrel

Associations of PER3 polymorphisms with clopidogrel resistance among Chinese Han people treated with clopidogrel

Background: Changes in circadian rhythm are related to various diseases, such as immune system diseases and cardiovascular diseases. The PERIOD3 (PER3) clock gene is one of the most important genes in the rhythm regulation system. Our goal was to evaluate the possible association between the PER3 rs...

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Bibliographic Details
Main Authors: Chen, X. (Author), Su, J. (Author), Xu, Z. (Author), Yang, J. (Author), Yin, F. (Author), Yu, Q. (Author), Zheng, N. (Author), Zhong, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
acetylsalicylic acid
acute coronary syndrome
adult
aged
Aged
albumin
albumin blood level
Article
Asian continental ancestry group
Asian Continental Ancestry Group
Blood Platelets
case control study
Case-Control Studies
circadian rhythm signaling protein
clopidogrel
Clopidogrel
clopidogrel resistance
controlled study
drug effect
drug resistance
Drug Resistance
ethnic group
Ethnic Groups
female
Female
gene
gene frequency
genetic association
Genetic Association Studies
genetic association study
genetic risk
genetics
genotype
groups by age
Han Chinese
high risk patient
human
human cell
Humans
loading drug dose
Logistic Models
major clinical study
male
Male
metabolism
middle aged
Middle Aged
multivariate analysis
Multivariate Analysis
PER3 gene
PER3 protein, human
percutaneous coronary interventions
Period Circadian Proteins
PERIOD3
platelet count
plateletcrit
Polymorphism, Single Nucleotide
single nucleotide polymorphism
single-nucleotide polymorphisms
statistical model
therapy resistance
thrombocyte
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