GC-MS metabolomics identifies novel biomarkers to distinguish tuberculosis pleural effusion from malignant pleural effusion

GC-MS metabolomics identifies novel biomarkers to distinguish tuberculosis pleural effusion from malignant pleural effusion

Background: Tuberculous pleural effusions (TBPEs) and malignant pleural effusions (MPEs) are two of the most common and severe forms of exudative effusions. Clinical differentiation is challenging; however, metabolomics is a collection of powerful tools currently being used to screen for disease-spe...

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Bibliographic Details
Main Authors: Cai, L. (Author), Chen, D. (Author), Liu, Y. (Author), Mei, B. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
aged
Aged
Article
biochemical analysis
biological marker
biomarker
Biomarkers
citric acid
clinical article
cluster analysis
Cluster Analysis
controlled study
creatinine
cystine
Diagnosis, Differential
diagnostic test accuracy study
diagnostic value
differential diagnosis
fatty acid
female
Female
Gas Chromatography-Mass Spectrometry
GC-MS
glycine
human
Humans
male
Male
malignant pleura effusion
malignant pleural effusion
mass fragmentography
Metabolic Networks and Pathways
metabolism
metabolite
metabolome
Metabolome
metabolomics
Metabolomics
middle aged
Middle Aged
multivariate analysis
Multivariate Analysis
oleamide
ornithine
pleura effusion
Pleural Effusion, Malignant
principal component analysis
Principal Component Analysis
pyroglutamic acid
quantitative analysis
receiver operating characteristic
reproducibility
Reproducibility of Results
ROC Curve
sensitivity and specificity
stearic acid
tuberculosis
Tuberculosis
tuberculosis pleural effusion
tuberculous pleural effusion
urea
valine
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