A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population

A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population

Background: Ischemic stroke (IS) is a serious global health burden. In order to improve our understanding of the risk factors associated with IS, we investigated the combined effect of the methylation of five genes related to the metabolism of homocysteine on developing IS. Methods: Quantitative met...

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Bibliographic Details
Main Authors: Chen, H. (Author), Dai, S. (Author), Han, L. (Author), Li, B. (Author), Li, C. (Author), Li, Y. (Author), Liang, Y. (Author), Lv, C. (Author), Peng, X. (Author), Tang, B. (Author), Wang, C. (Author), Wang, L. (Author), Xu, S. (Author), Zhang, T. (Author), Zhu, L. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adenosylhomocysteinase
Adenosylhomocysteinase
adult
aged
Aged
AHCY protein, human
amino acid metabolism
area under the curve
Article
Asian continental ancestry group
Asian Continental Ancestry Group
association
brain ischemia
case control study
Case-Control Studies
CBS gene
China
complication
controlled study
Cross-Sectional Studies
cross-sectional study
cystathionine beta synthase
Cystathionine beta-Synthase
DHFR gene
dihydrofolate reductase
DNA methylation
DNA Methylation
female
Female
genetic association
genetics
glycine hydroxymethyltransferase
Glycine Hydroxymethyltransferase
homocysteine
Homocysteine
human
Humans
hyperhomocysteine
hypertension
Hypertension
ischemic stroke
Ischemic Stroke
major clinical study
male
Male
metabolism
methylenetetrahydrofolate dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP)
middle aged
Middle Aged
minor histocompatibility antigen
Minor Histocompatibility Antigens
MTHFD1 gene
MTHFD1 protein, human
promoter region
quantitative methylation specific polymerase chain reaction
receiver operating characteristic
risk factor
SHMT protein, human
Tetrahydrofolate Dehydrogenase
Youden index
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