Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti-tuberculosis drug-induced hepatotoxicity: A prospective study

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti-tuberculosis drug-induced hepatotoxicity: A prospective study

Background: The role of collagen type XVIII alpha 1 chain (COL18A1) in anti-tuberculosis drug-induced hepatotoxicity (ATDH) has not been reported. This study aimed to explore the association between of COL18A1 variants and ATDH susceptibility. Methods: A total of 746 patients were enrolled in our st...

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Bibliographic Details
Main Authors: Cheng, Y. (Author), Jiao, L. (Author), Lai, H. (Author), Li, W. (Author), Lin, Z. (Author), Wang, J. (Author), Ying, B. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
age
allele
alpha chain
Antitubercular Agents
anti-tuberculosis drug-induced hepatotoxicity
Article
Asian continental ancestry group
Asian Continental Ancestry Group
categorical variable
Chemical and Drug Induced Liver Injury
chi square test
COL18A1
COL18A1 gene
COL18A1 protein
COL18A1 protein, human
collagen type 18
Collagen Type XVIII
controlled study
diagnostic accuracy
disease association
disease predisposition
ethambutol
female
Female
Fisher exact test
gender
gene
gene frequency
Gene Frequency
genetic model
genetic polymorphisms
genetics
genotype
Han Chinese
haplotype
Haplotypes
homozygote
human
Humans
informed consent
isoniazid
Logistic Models
major clinical study
male
Male
mathematical variable
middle aged
Middle Aged
multivariate logistic regression analysis
odds ratio
patient
personalized medicine
Polymorphism, Single Nucleotide
prediction
Prospective Studies
prospective study
protein
pyrazinamide
rank sum test
rifampicin
risk
risk reduction
single nucleotide polymorphism
statistical model
susceptibility
toxic hepatitis
tuberculosis
tuberculostatic agent
unclassified drug
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