Microglial Annexin A3 promoted the development of melanoma via activation of hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway

Microglial Annexin A3 promoted the development of melanoma via activation of hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway

Background: Melanoma, a relatively common malignancy, has become one of the tumors with the fastest rising incidence in recent years. The purpose of this study was to investigate the effect of Microglial Annexin A3 (ANXA3) on melanoma. Methods: Serum samples were obtained from 20 patients with melan...

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Bibliographic Details
Main Authors: Gao, Y. (Author), Shi, B. (Author), Song, J. (Author), Xu, B. (Author), Zhang, X. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
Annexin A3
ANXA3
ANXA3 protein, human
Article
blood
case control study
Case-Control Studies
caspase 3
caspase 9
cell growth
cell invasion assay
Cell Line, Tumor
cell migration
cell motion
Cell Movement
cell proliferation assay
clinical article
controlled study
cytotoxicity
disease free survival
down regulation
enzyme activation
enzyme inhibition
genetics
glycerophosphoinositol inositolphosphodiesterase
HIF1A protein, human
HIF-1α
human
human cell
human tissue
Humans
hypoxia inducible factor 1alpha
Hypoxia-Inducible Factor 1, alpha Subunit
lactate dehydrogenase
melanoma
Melanoma
messenger RNA
metabolism
microglia
migration
mortality
overall survival
pathology
plasmid
protein expression
protein function
protein RNA binding
real time polymerase chain reaction
signal transduction
Skin Neoplasms
skin tumor
tumor cell line
upregulation
Vascular Endothelial Growth Factor A
vasculotropin
vasculotropin A
VEGF
VEGFA protein, human
Western blotting
wound healing assay
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