Prospective case-control study of enterovirus detection differences in children’s cerebrospinal fluid between multiplex PCR and real-time RT-PCR assay

Background: Viral encephalitis is common in childhood. It is an acute brain parenchymal inflammation caused by a variety of viral infection, and enterovirus accounts for the majority. Due to atypical clinical manifestations, pathogenic testing is important for assisting clinical diagnosis. The purpo...

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Bibliographic Details
Main Authors:	Chen, F. (Author), Guo, Y. (Author), Li, J. (Author), Sun, S. (Author), Wang, L. (Author), Wang, W. (Author), Yang, F. (Author), You, D. (Author), Zeng, X. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	Article case control study Case-Control Studies central nervous system disease cerebrospinal fluid child Child Child, Preschool children coinfection comparative study controlled study diagnostic test accuracy study Encephalitis, Viral enterovirus Enterovirus Enterovirus infection Enterovirus Infections epilepsy Epstein Barr virus infection false negative result false positive result female Female genetics hospital discharge human Humans intermethod comparison major clinical study male Male multiplex PCR multiplex polymerase chain reaction Multiplex Polymerase Chain Reaction mumps pediatric patient preschool child procedures Prospective Studies prospective study real time polymerase chain reaction real time reverse transcription polymerase chain reaction real-time PCR Real-Time Polymerase Chain Reaction sensitivity and specificity Sensitivity and Specificity virology virus detection virus encephalitis
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Prospective case-control study of enterovirus detection differences in children’s cerebrospinal fluid between multiplex PCR and real-time RT-PCR assay

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