Orientational changes of white matter fibers in Alzheimer's disease and amnestic mild cognitive impairment

White matter abnormalities represent early neuropathological events in neurodegenerative diseases such as Alzheimer's disease (AD), investigating these white matter alterations would likely provide valuable insights into pathological changes over the course of AD. Using a novel mathematical fra...

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Bibliographic Details
Main Authors:	Basser, P.J (Author), Cheng, J. (Author), for the Alzheimer's Disease Neuroimaging Initiative (Author), Jiang, J. (Author), Koch, F. (Author), Liu, T. (Author), Sachdev, P.S (Author), Wen, W. (Author), Zhao, H. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	aged Aged Aged, 80 and over Alzheimer disease Alzheimer Disease Alzheimer's disease amnesia Amnesia amnestic mild cognitive impairment Article brain atrophy brain lateral ventricle Clinical Dementia Rating cognition cognitive defect Cognitive Dysfunction diagnostic imaging diffusion tensor imaging Diffusion Tensor Imaging echo planar imaging female Female fractional anisotropy geometric microstructure gray matter gray matter volume human Humans image processing inferior longitudinal fasciculus major clinical study male Male mean diffusivity memory mild cognitive impairment Mini Mental State Examination myelinated nerve Nerve Fibers, Myelinated neuroimaging nuclear magnetic resonance imaging occipitofrontal fasciculus orientation change pathology positron emission tomography pyramidal tract superior longitudinal fasciculus thalamus anterior nucleus uncinate fasciculus very elderly Wechsler memory scale white matter White Matter
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Orientational changes of white matter fibers in Alzheimer's disease and amnestic mild cognitive impairment

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