225 Ac-rHDL Nanoparticles: A Potential Agent for Targeted Alpha-Particle Therapy of Tumors Overexpressing SR-BI Proteins

225 Ac-rHDL Nanoparticles: A Potential Agent for Targeted Alpha-Particle Therapy of Tumors Overexpressing SR-BI Proteins

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Actinium-225 and other alpha-particle-emitting radionuclides have shown high potential for cancer treatment. Reconstituted high-density lipoproteins (rHDL) specifically recognize the scavenger receptor B type I (SR-BI) overexpressed in several types of cancer cells. Furthermore, after rHDL-SR-BI rec...

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Bibliographic Details
Main Authors: Aranda-Lara, L. (Author), De Nardo, L. (Author), Ferro-Flores, G. (Author), Hernández-Jiménez, T. (Author), Isaac-Olivé, K. (Author), Luna-Gutiérrez, M. (Author), Meléndez-Alafort, L. (Author), Morales-ávila, E. (Author), Ocampo-García, B. (Author), Rosato, A. (Author), Santos-Cuevas, C. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
225 Ac-rHDL
actinium-225
Alpha Particles
alpha radiation
animal
Animals
chemistry
high density lipoprotein
Lipoproteins, HDL
Mice
mouse
nanoparticle
Nanoparticles
neoplasm
Neoplasms
Receptors, Scavenger
reconstituted high-density lipoproteins
scavenger receptor
scavenger receptor B type I
targeted alpha-particle therapy
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