Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes

Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes

Investigation of erythrocytes from spontaneous or engineered germ-line mutant mice has been instrumental in characterizing the physiological functions of components of the red cell cytoskeleton and membrane. However, the red blood cell expresses some proteins whose germline loss-of-function is embry...

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Bibliographic Details
Main Authors: Alper, S.L (Author), Brugnara, C. (Author), Dlott, J.S (Author), Hsu, A. (Author), Michael Snyder, L. (Author), Nishimura, K. (Author), Rivera, A. (Author), Shmukler, B.E (Author), Wohlgemuth, J. (Author)
Format: Article
Language:English
Published: American Physiological Society 2022
Subjects:
adult
allele
animal cell
animal experiment
animal model
Article
atomic absorption spectrometry
centrifugation
controlled study
cre recombinase
cytoskeleton
erythroblast
erythrocyte
erythropoietin receptor
gene
gene expression
genetic transcription
genotype
germ line
hematocrit
hormone
ion transport
LoxP site
megalocytosis
membrane protein
mouse
mutation
nonhuman
peptide
peptide hormone
potassium chloride cotransporter
progeny
protein expression
protein function
protein tyrosine kinase inhibitor
radioisotopic flux
recombinase
red blood cell
reticulocytosis
serine
signal transduction
sodium chloride
sodium transport
staurosporine
threonine
tissue-specific knockout
transcription factor
transgene
urea
weaning
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