Pan-Caspase Inhibitor zVAD Induces Necroptotic and Autophagic Cell Death in TLR3/4-Stimulated Macrophages

Pan-Caspase Inhibitor zVAD Induces Necroptotic and Autophagic Cell Death in TLR3/4-Stimulated Macrophages

In addition to inducing apoptosis, caspase inhibition contributes to necroptosis and/or autophagy depending on the cell type and cellular context. In macrophages, necroptosis can be induced by co-treatment with Toll-like receptor (TLR) ligands (lipopolysaccharide [LPS] for TLR4 and polyinosinic-poly...

Full description

Bibliographic Details
Main Authors: Chen, Y.-S (Author), Cheng, C.-Y (Author), Chuang, W.-C (Author), Huang, D.-Y (Author), Kung, H.-N (Author), Lin, W.-W (Author), Sekar, P. (Author)
Format: Article
Language:English
Published: Korean Society for Molecular and Cellular Biology 2022
Subjects:
Autophagic Cell Death
autophagy
caspase
caspase inhibitor
Caspase Inhibitors
Caspases
interferon
JAK/STAT1
ligand
Ligands
lipopolysaccharide
Lipopolysaccharides
macrophage
Macrophages
metabolism
necrosis
Poly I
polyinosinic acid
protein kinase B
Proto-Oncogene Proteins c-akt
reactive oxygen metabolite
Reactive Oxygen Species
toll like receptor 3
Toll-Like Receptor 3
zVAD
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items