PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

Host defense systems employ posttranslational modifications to protect against invading pathogens. Here, we found that protein inhibitor of activated STAT 1 (PIAS1) interacts with the nucleoprotein (NP), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2) of influenza A virus (IAV...

Full description

Bibliographic Details
Main Authors: Chen, H. (Author), Deng, G. (Author), Jiang, L. (Author), Kong, F. (Author), Li, C. (Author), Liang, L. (Author), Liu, L. (Author), Shi, J. (Author), Tian, G. (Author), Wang, G. (Author), Wang, X. (Author), Wang, Y. (Author), Wen, X. (Author), Yan, Y. (Author), Zeng, X. (Author), Zhao, Y. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: Public Library of Science 2022
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items