RhoA/ROCK signaling antagonizes bovine trophoblast stem cell self-renewal and regulates preimplantation embryo size and differentiation

RhoA/ROCK signaling antagonizes bovine trophoblast stem cell self-renewal and regulates preimplantation embryo size and differentiation

Exponential proliferation of trophoblast stem cells (TSC) is crucial in Ruminantia to maximize numerical access to caruncles, the restricted uterine sites that permit implantation. When translating systems biology of the undifferentiated bovine trophectoderm, we uncovered that inhibition of RhoA/Roc...

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Bibliographic Details
Main Authors: Cheong, S.H (Author), Das, M. (Author), Gurung, S. (Author), Hansen, P.J (Author), Kei, T.G (Author), Pillai, V.V (Author), Selvaraj, V. (Author), Siqueira, L.G.B (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
blastocyst
Blastocyst
bovine
Cattle
cell differentiation
Cell Differentiation
Cell Self Renewal
cell self-renewal
female
Female
Implantation
placenta
Placenta
pregnancy
Pregnancy
Stem cells
trophoblast
Trophoblast
Trophoblasts
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