The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

Background: The gut microbiota can affect neurologic disease by shaping microglia, the primary immune cell in the central nervous system (CNS). While antibiotics improve models of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and the C9orf72 model of amyotrophic lateral sclerosis (AL...

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Bibliographic Details
Main Authors: Butovsky, O. (Author), Calcagno, N. (Author), Cox, L.M (Author), Gauthier, C. (Author), Madore, C. (Author), Weiner, H.L (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adult
Akkermansia
ampicillin
amyotrophic lateral sclerosis
animal experiment
animal model
antibiotic agent
apolipoprotein E
Article
autophagosome
Bacteroidetes
cefoperazone
central nervous system
colistin
complementary DNA
controlled study
copper zinc superoxide dismutase
degenerative disease
DNA extraction
down regulation
drug megadose
female
fluorescence activated cell sorting
gene expression
genetic risk
genotype
gentamicin
immunocompetent cell
interleukin 17
intestine flora
kanamycin
Lachnospiraceae
Lactobacillus
male
metronidazole
microbiome
microflora
microglia
motor performance
mouse
multiple sclerosis
neomycin
nonhuman
Parkinson disease
phenotype
probiotic agent
protein function
Proteobacteria
RNA 16S
RNA sequence
RNA sequencing
rotarod test
Ruminococcus
sodium blood level
upregulation
vancomycin
wild type mouse
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