High-resolution genomic surveillance elucidates a multilayered hierarchical transfer of resistance between WWTP- and human/animal-associated bacteria

High-resolution genomic surveillance elucidates a multilayered hierarchical transfer of resistance between WWTP- and human/animal-associated bacteria

Background: Our interconnected world and the ability of bacteria to quickly swap antibiotic resistance genes (ARGs) make it particularly important to establish the epidemiological links of multidrug resistance (MDR) transfer between wastewater treatment plant (WWTP)- and human/animal-associated bact...

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Bibliographic Details
Main Authors: Břinda, K. (Author), Che, Y. (Author), Hanage, W. (Author), Xu, X. (Author), Yang, C. (Author), Yang, Y. (Author), Zhang, T. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
ampicillin
animal
Animals
Anti-Bacterial Agents
antibiotic resistance
antiinfective agent
Article
Bacteria
bacterial genome
bacterial virulence
bacterium
bacterium isolate
bacterium isolation
chloramphenicol
Citrobacter portucalensis
comparative genomics
conjugative plasmid
DNA extraction
DNA sequencing
DNA transfer
ecological niche
Escherichia coli
Escherichia dysenteriae
Escherichia flexneri
evolutionary adaptation
gene insertion sequence
genetic background
genetics
genome analysis
genomic DNA
Genomic epidemiology
genomic surveillance
genomics
Genomics
hierarchical clustering
horizontal gene transfer
Horizontal gene transfer
human
Humans
illumina sequencing
Insertion sequences
kanamycin
Klebsiella pneumoniae
klebsiella quasipneumoniae
MDR
multidrug resistant bacterium
multilayered hierarchical transfer
multilocus sequence typing
Nanopore
nanopore sequencing
nonhuman
pangenome
phylogeny
plasmid
Plasmidome
Plasmids
population genomics
prevalence
Proteus mirabilis
Raoultella ornithinolytica
Shigella flexneri
single nucleotide polymorphism
tetracycline
virulence factor
waste water management
waste water treatment plant
water management
Water Purification
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