Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy

Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy

Background: Various methods have been developed to generate hepatic cells from human pluripotent stem cells (hPSCs) that rely on the combined use of multiple expensive growth factors, limiting industrial-scale production and widespread applications. Small molecules offer an attractive alternative to...

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Bibliographic Details
Main Authors: Chen, Y. (Author), Fang, J. (Author), Gao, Y. (Author), Li, S. (Author), Li, Y. (Author), Li, Y.-X (Author), Liang, K. (Author), Lin, X. (Author), Pan, T. (Author), Wang, N. (Author), Xu, Y. (Author), Yang, F. (Author), You, K. (Author), Zhang, J. (Author), Zhuang, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
biological therapy
Cell- and Tissue-Based Therapy
cell differentiation
Cell Differentiation
Hepatic differentiation
Hepatoblasts
Hepatocyte-like cells
Hepatocytes
human
Human pluripotent stem cells
Humans
induced pluripotent stem cell
Induced Pluripotent Stem Cells
Intercellular Signaling Peptides and Proteins
liver
Liver
liver cell
metabolism
pluripotent stem cell
Pluripotent Stem Cells
signal peptide
Small molecule
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