Somatic mutational profiles and germline polygenic risk scores in human cancer

Somatic mutational profiles and germline polygenic risk scores in human cancer

Background: The mutational profile of cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational signatures. Mutational signatures, including single-...

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Bibliographic Details
Main Authors: Alexandrov, L.B (Author), Gusev, A. (Author), Heng, Y.J (Author), Kraft, P. (Author), Liu, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Article
biological trait
breast cancer
Breast Neoplasms
breast tumor
Cancer
cancer risk
estrogen receptor positive breast cancer
female
Female
genetic association
genetic risk
genetic risk score
genetic variation
genetics
genome-wide association study
Genome-Wide Association Study
germ cell
Germ Cells
human
Humans
major clinical study
male
Male
malignant neoplasm
menarche
mutation
Mutation
Mutational signature
Polygenic risk score
prostate cancer
risk factor
Risk Factors
Single-base substitution signature
somatic mutation
Somatic mutation
whole exome sequencing
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