Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL

Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL

Asparaginase therapy is a key component of chemotherapy for patients with T-cell acute lymphoblastic leukemia (T-ALL). Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine synthetase (ASNS) activity, whereas leukemia cells...

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Bibliographic Details
Main Authors: Akahane, K. (Author), Goi, K. (Author), Harama, D. (Author), Hata, K. (Author), Horibe, K. (Author), Imamura, T. (Author), Inukai, T. (Author), Kagami, K. (Author), Kasai, S. (Author), Kawai, T. (Author), Kimura, S. (Author), Kiyokawa, N. (Author), Koh, K. (Author), Minegishi, M. (Author), Miyake, K. (Author), Shinohara, T. (Author), Sugita, K. (Author), Takita, J. (Author), Thomas Look, A. (Author), Watanabe, A. (Author), Yoshimura, K. (Author)
Format: Article
Language:English
Published: American Society of Hematology 2022
Subjects:
acute lymphoblastic leukemia
acute T-cell leukemia cell line
Article
asparaginase
aspartate ammonia ligase
bisulfite sequencing polymerase chain reaction
cancer prognosis
controlled study
DNA methylation
drug resistance
drug sensitivity
gene cluster
high throughput sequencing
human
human cell
T cell lymphoblastic leukemia cell
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