Diminished androgen levels are linked to irritable bowel syndrome and cause bowel dysfunction in mice

Diminished androgen levels are linked to irritable bowel syndrome and cause bowel dysfunction in mice

Functional gastrointestinal disorders (FGIDs) have prominent sex differences in incidence, symptoms, and treatment response that are not well understood. Androgens are steroid hormones present at much higher levels in males than females and could be involved in these differences. In adults with irri...

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Bibliographic Details
Main Authors: Ballou, S. (Author), Dan, W. (Author), Hall, K. (Author), Hassan, R. (Author), Lagomarsino, V.N (Author), Lembo, A. (Author), Matthews, L.T (Author), Mixer, M. (Author), Nee, J. (Author), Perez, K. (Author), Prochera, A. (Author), Rao, M. (Author), Rastelli, D. (Author), Robinson, A. (Author), Shepherd, A. (Author), Sun, L. (Author), Yim, P.D (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
Subjects:
adult
Adult
androgen
androgen blood level
androgen deficiency
androgen receptor
Androgens
androstanolone
animal
animal experiment
animal model
Animals
Article
biosynthesis
blood
colon
Colon
colon motility
controlled study
depletion
female
Female
gastrointestinal motility
Gastrointestinal Motility
gastrointestinal transit
glia
gonad
high throughput sequencing
human
Humans
in vivo study
interstitial cell of Cajal
intestinal dysmotility
intestine function
intestine innervation
intestine motility
Irritable Bowel Syndrome
irritable colon
locomotion
macrophage
male
Male
mass spectrometry
metabolism
Mice
mouse
nonhuman
orchiectomy
pathophysiology
protein expression
puberty
Receptors, Androgen
signal transduction
smooth muscle cell
symptom
syncytium
testosterone
testosterone blood level
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