Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum

Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum

Objective Although immunoglobulin A (IgA) is abundantly expressed in the gut and known to be an important component of mucosal barriers against luminal pathogens, its precise function remains unclear. Therefore, we tried to elucidate the effect of IgA on gut homeostasis maintenance and its mechanism...

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Bibliographic Details
Main Authors: Adachi, T. (Author), Aida, T. (Author), Blumberg, R.S (Author), Hirakata, S. (Author), Hirayama, K. (Author), Ishino, F. (Author), Karasuyama, H. (Author), Kawasaki, H. (Author), Kotake, K. (Author), Kumazawa, T. (Author), Miura, T. (Author), Nagaishi, T. (Author), Okamoto, R. (Author), Ono, R. (Author), Tanaka, K. (Author), Tsugawa, N. (Author), Usami, T. (Author), Watabe, T. (Author), Watanabe, M. (Author), Yamada, D. (Author), Yoshikawa, S. (Author)
Format: Article
Language:English
Published: BMJ Publishing Group 2022
Subjects:
allele
animal
animal cell
animal experiment
animal model
animal tissue
Animals
Article
B lymphocyte
B-Lymphocytes
calcium ion
CD4 antigen
CD4+ T lymphocyte
cell activation
controlled study
CRISPR-CAS9 system
cytokine
cytokine production
Cytokines
cytoplasm
disease model
Disease Models, Animal
embryo
enteritis
female
Female
gamma interferon
Gastrointestinal Microbiome
homeostasis
Homeostasis
IgA
ileitis
Ileitis
ileum
Ileum
ileum mucosa
immunocompetent cell
immunoglobulin A
Immunoglobulin A
immunoglobulin A deficiency
immunoglobulin production
infant
inflammation
Inflammation
interleukin 17
intestinal bacteria
intestine flora
intravital microscopy
Intravital Microscopy
male
Male
metabolism
Mice
Mice, Mutant Strains
mouse
mucosal barrier
mutant
mutant mouse strain
newborn
nonhuman
pathology
Peyer patch
physiology
small intestine
T lymphocyte
T-Lymphocytes
ultrastructure
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