Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling

There is growing interest in the potential use of phosphodiesterase (PDE) inhibitors for colorectal cancer (CRC) prevention and treatment. The present study has tested the idea that PDE inhibitors inhibit growth and viability of CRC cell lines by increasing cyclic guanosine monophosphate (cGMP) and...

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Bibliographic Details
Main Authors: Browning, D.D (Author), Browning, K. (Author), Hou, Y. (Author), Islam, B.N (Author), Mylarapu, N. (Author), Vega, K.J (Author), Wang, R. (Author), Wren, A. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Online Access:View Fulltext in Publisher