Retron reverse transcriptase termination and phage defense are dependent on host RNase H1

Retrons are bacterial retroelements that produce single-stranded, reverse-transcribed DNA (RT-DNA) that is a critical part of a newly discovered phage defense system. Short retron RT-DNAs are produced from larger, structured RNAs via a unique 2′-5′ initiation and a mechanism for precise termination...

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Bibliographic Details
Main Authors: Bhattarai-Kline, S. (Author), Fishman, C.B (Author), Myers, S.A (Author), Palka, C. (Author), Shipman, S.L (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Online Access:View Fulltext in Publisher