Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway

Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway

Experimental autoimmune encephalomyelitis (EAE) is characterized by demyelination of the central nervous system. Emodin is an anthraquinone derivative with comprehensive anti-inflammatory, anti-cancer, and immunomodulatory effects and is widely used in the treatment of inflammatory, tumor, and immun...

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Bibliographic Details
Main Authors: Li, X. (Author), Lv, B. (Author), Wang, C. (Author), Wu, L. (Author), Wu, Z. (Author), Xu, H. (Author), Zhao, Y. (Author), Zheng, K. (Author), Zheng, Z. (Author)
Format: Article
Language:English
Published: Taylor and Francis Ltd. 2022
Subjects:
animal
Animals
antiinflammatory agent
Anti-Inflammatory Agents
C57BL mouse
emodin
Emodin
Encephalomyelitis, Autoimmune, Experimental
experimental autoimmune encephalomyelitis
immunoglobulin enhancer binding protein
inflammation
Inflammation
metabolism
Mice
Mice, Inbred C57BL
microglia
Microglia
microglia activation
molecular docking
Molecular Docking Simulation
mouse
MS/EAE
Myd88 protein, mouse
myelin protective
myeloid differentiation factor 88
Myeloid Differentiation Factor 88
network pharmacology
NF-kappa B
pathology
phosphatidylinositol 3 kinase
Phosphatidylinositol 3-Kinases
PI3K/AKT/NF- κB signalling pathway
protein kinase B
Proto-Oncogene Proteins c-akt
spinal cord
Spinal Cord
TLRs/MyD88 signal
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