Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

Studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. The biological mechanism underlying this effect is unclear but is likely to be independent of body size in adulthood. Using a Mendelian randomization framework, we investigate 18 hypothesised mediators of...

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Bibliographic Details
Main Authors: Davey Smith, G. (Author), Lloyd-Lewis, B. (Author), Richardson, T.G (Author), Richmond, R.C (Author), Sanderson, E. (Author), Vabistsevits, M. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
Adiposity
adult
Adult
body mass
Body Mass Index
Breast Neoplasms
breast tumor
childhood obesity
female
Female
genetics
human
Humans
Mendelian randomization analysis
Mendelian Randomization Analysis
obesity
Pediatric Obesity
Polymorphism, Single Nucleotide
risk factor
Risk Factors
single nucleotide polymorphism
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