Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed structural variations (SV) with a predominance of deletions, tandem duplication...

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Bibliographic Details
Main Authors: Abbas, S. (Author), Contino, G. (Author), Devonshire, G. (Author), Edwards, P.A.W (Author), Eldridge, M.D (Author), Fitzgerald, R.C (Author), Hsu, R. (Author), Killcoyne, S. (Author), Ng, A.W.T (Author), Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium (Author), Redmond, A.M (Author), Su, J. (Author), Tavaré, S. (Author), Weaver, J.M.J (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
adenocarcinoma
Adenocarcinoma
Esophageal Neoplasms
esophagus tumor
genetics
Genome, Human
histone acetyltransferase
Histone Acetyltransferases
human
human genome
Humans
KAT6B protein, human
whole genome sequencing
Whole Genome Sequencing
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