CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer

CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer

Background and aims: CDH1 germline variants have been linked to heritability in diffuse gastric (DGC) and lobular breast cancer (LBC). Studies have not yet assessed whether CDH1 is a cancer-susceptibility gene in other cancers. Herein, we mapped the landscape of pathogenic and likely pathogenic (P/L...

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Main Authors: Abou Alaiwi, S. (Author), Adib, E. (Author), Akl, E.W (Author), Choueiri, T.K (Author), El Zarif, T. (Author), Esplin, E.D (Author), Hatchell, K. (Author), Kwiatkowski, D.J (Author), Mouhieddine, T.H (Author), Nassar, A.H (Author), Nielsen, S.M (Author), Rana, H.Q (Author), Sonpavde, G. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
Subjects:
adult
Adult
aged
Aged
Antigens, CD
Breast Neoplasms
breast tumor
cadherin
Cadherins
Carcinoma, Lobular
Carcinoma, Signet Ring Cell
CDH1 protein, human
Colorectal Neoplasms
colorectal tumor
DNA sequence
ethnology
female
Female
genetic predisposition
Genetic Predisposition to Disease
genetics
germline mutation
Germ-Line Mutation
high throughput sequencing
High-Throughput Nucleotide Sequencing
human
Humans
leukocyte antigen
lobular carcinoma
male
Male
middle aged
Middle Aged
mutation rate
Mutation Rate
prevalence
Prevalence
Sequence Analysis, DNA
signet ring carcinoma
Stomach Neoplasms
stomach tumor
young adult
Young Adult
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