Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression

Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression

Animal and human studies have documented the existence of developmental windows (or sensitive periods) when experience can have lasting effects on brain structure or function, behavior, and disease. Although sensitive periods for depression likely arise through a complex interplay of genes and exper...

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Bibliographic Details
Main Authors: Crawford, K.M (Author), Davis, K.A (Author), de Leeuw, C. (Author), Dunn, E.C (Author), Hensch, T.K (Author), Lussier, A.A (Author), Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (Author), Ramírez-Tapia, J.C (Author), Smoller, J.W (Author), Takesian, A.E (Author), Wang, M.-J (Author), Zhu, Y. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
Subjects:
age
amygdala
Article
autopsy
brain
Brain
brain region
Child, Preschool
childhood adversity
comparative study
controlled study
depression
Depression
developmental stage
differential gene expression
disease predisposition
emotional abuse
female
gene control
gene interaction
gene set analysis
genetic association
genetic risk
genetic risk score
genetic transcription
genetic variability
genetics
genome-wide association study
Genome-Wide Association Study
genotype
hippocampus
human
human tissue
Humans
infant
Infant
Life Change Events
life event
major clinical study
major histocompatibility complex
male
medial prefrontal cortex
multicenter study
neuropathology
phenotype
population research
preschool child
risk factor
Risk Factors
RNA translation
sensitivity analysis
sex difference
single nucleotide polymorphism
United Kingdom
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