Prefusion spike protein conformational changes are slower in SARS-CoV-2 than in SARS-CoV-1

Prefusion spike protein conformational changes are slower in SARS-CoV-2 than in SARS-CoV-1

Within the last 2 decades, severe acute respiratory syndrome coronaviruses 1 and 2 (SARS-CoV-1 and SARS-CoV-2) have caused two major outbreaks; yet, for reasons not fully understood, the coronavirus disease 2019 pandemic caused by SARS-CoV-2 has been significantly more widespread than the 2003 SARS...

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Bibliographic Details
Main Authors: Isu, U.H (Author), Kumar, V.G (Author), Losey, J. (Author), Moradi, M. (Author), Ogden, D.S (Author), Polasa, A. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Activation energy
Angiotensin-converting enzyme 2
Binding energy
Biochemistry
Coronaviruses
Diseases
Enzymes
Host cells
Mechanistics
Molecular dynamics
Potential sources
Protein conformational changes
Protein-binding
SARS
SARS epidemics
Severe acute respiratory syndrome coronavirus
Spike protein
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