Identification of cis-regulatory modules for adeno-associated virus-based cell-type-specific targeting in the retina and brain

Identification of cis-regulatory modules for adeno-associated virus-based cell-type-specific targeting in the retina and brain

Adeno-associated viruses (AAVs) targeting specific cell types are powerful tools for studying distinct cell types in the central nervous system (CNS). Cis-regulatory modules (CRMs), e.g., enhancers, are highly cell-type-specific and can be integrated into AAVs to render cell type specificity. Chroma...

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Bibliographic Details
Main Authors: Chan, C.S.Y (Author), Chen, L. (Author), Davis, A.E (Author), Ding, J.B (Author), Emerson, M.M (Author), Gu, B. (Author), Gu, L. (Author), Lin, C.-H (Author), Sun, Y. (Author), Tanasa, B. (Author), Wang, S. (Author), Wu, M.-R (Author), Zhang, W. (Author), Zhong, L.R (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Adeno-associated virus
Binding sites
Cell types
Central nervous systems
Cis-regulatory modules
Cytology
Digital storage
Efficiency
Genes expression
In-vivo
Labelings
Large dataset
Large-scale datasets
Module-based
Molecular biology
Neurons
Prescreening
Transcription
Viruses
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