Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis: Correlation with Neutrophil but Not Endothelial Activation

Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis: Correlation with Neutrophil but Not Endothelial Activation

Severe coronavirus disease 2019 (COVID-19) increases the risk of myocardial injury that contributes to mortality. This study used multiparameter immunofluorescence to extensively examine heart autopsy tissue of 7 patients who died of COVID-19 compared to 12 control specimens, with or without cardiov...

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Bibliographic Details
Main Authors: Jane-Wit, D. (Author), Johnson, J.E (Author), Libby, P. (Author), McGuone, D. (Author), Mitchell, R.N (Author), Pober, J.S (Author), Xu, M.L (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
adult
aged
Aged
Aged, 80 and over
anticoagulant agent
anticoagulant therapy
Article
autopsy
Blood Platelets
blood vessel
cardiac muscle
cardiovascular disease
cell activation
cell death
clinical article
cohort analysis
controlled study
coronary artery thrombosis
coronary blood vessel
Coronary Vessels
coronavirus disease 2019
correlational study
COVID-19
endothelium
Endothelium, Vascular
extracellular trap
female
Female
fluorescence microscopy
gene expression
gene expression regulation
Gene Expression Regulation
heart tissue
human
human cell
human tissue
Humans
ICAM 1 gene
immunofluorescence
intercellular adhesion molecule 1
leukocyte activation
male
Male
metabolism
middle aged
Middle Aged
mortality
myocarditis
Myocarditis
Myocardium
neutrophil
Neutrophil Activation
Neutrophils
pandemic
pathology
Platelet Aggregation
RelA gene
SARS-CoV-2
STAT1 gene
STAT1 protein
STAT3 gene
STAT3 protein
TF gene
thrombocyte
thrombocyte aggregation
thromboplastin
thrombosis
Thrombosis
transcription factor RelA
vascular cell adhesion molecule 1
vascular endothelium
very elderly
von Willebrand factor
VWF gene
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