Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data fr...

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Main Authors: Aguilar-Salinas, C.A (Author), AMP-T2D-GENES, Myocardial Infarction Genetics Consortium (Author), Antonacci-Fulton, L. (Author), Ardissino, D. (Author), Arnett, D.K (Author), Aslibekyan, S. (Author), Atzmon, G. (Author), Ballantyne, C.M (Author), Barajas-Olmos, F. (Author), Barzilai, N. (Author), Becker, L.C (Author), Bielak, L.F (Author), Bis, J.C (Author), Blangero, J. (Author), Boehnke, M. (Author), Boerwinkle, E. (Author), Bonnycastle, L.L (Author), Bottinger, E. (Author), Bowden, D.W (Author), Bown, M.J (Author), Brody, J.A (Author), Broome, J.G (Author), Burtt, N.P (Author), Cade, B.E (Author), Centeno-Cruz, F. (Author), Chaffin, M.D (Author), Chan, E. (Author), Chang, Y.-C (Author), Chen, Y.-D.I (Author), Cheng, C.-Y (Author), Choi, W.J (Author), Chowdhury, R. (Author), Contreras-Cubas, C. (Author), Córdova, E.J (Author), Correa, A. (Author), Cupples, L.A (Author), Curran, J.E (Author), Danesh, J. (Author), de Vries, P.S (Author), DeFronzo, R.A (Author), Doddapaneni, H. (Author), Dornbos, P. (Author), Duggirala, R. (Author), Dutcher, S.K (Author), Ellinor, P.T (Author), Emery, L.S (Author), Flannick, J.A (Author), Florez, J.C (Author), Fornage, M. (Author), Freedman, B.I (Author), Fuster, V. (Author), Garay-Sevilla, M.E (Author), García-Ortiz, H. (Author), Germer, S. (Author), Gibbs, R.A (Author), Gieger, C. (Author), Glaser, B. (Author), Gonzalez, C. (Author), Gonzalez-Villalpando, M.E (Author), Graff, M. (Author), Graham, S.E (Author), Grarup, N. (Author), Groop, L.C (Author), Guo, X. (Author), Gupta, N. (Author), Han, S. (Author), Hanis, C.L (Author), Hansen, T. (Author), He, J. (Author), Heard-Costa, N.L (Author), Hindy, G. (Author), Hung, Y.-J (Author), Hwang, M.Y (Author), Irvin, M.R (Author), Islas-Andrade, S. (Author), Jarvik, G.P (Author), Kang, H.M (Author), Kardia, S.L.R (Author), Kathiresan, S. (Author), Kelly, T. (Author), Kenny, E.E (Author), Khan, A.T (Author), Khera, A.V (Author), Kim, B.-J (Author), Kim, R.W (Author), Kim, Y.J (Author), Koistinen, H.A (Author), Kooperberg, C. (Author), Kuusisto, J. (Author), Kwak, S.H (Author), Laakso, M. (Author), Lange, L.A (Author), Lee, J. (Author), Lee, S. (Author), Lehman, D.M (Author), Lemaitre, R.N (Author), Linneberg, A. (Author), Liu, D.J (Author), Liu, J. (Author), Loos, R.J.F (Author), Lubitz, S.A (Author), Lyssenko, V. (Author), Ma, R.C.W (Author), Martin, L.W (Author), Martínez-Hernández, A. (Author), Mathias, R.A (Author), McCarthy, M.I (Author), McGarvey, S.T (Author), McPherson, R. (Author), Meigs, J.B (Author), Meitinger, T. (Author), Melander, O. (Author), Mendoza-Caamal, E. (Author), Metcalf, G.A (Author), Mi, X. (Author), Mohlke, K.L (Author), Montasser, M.E (Author), Moon, J.-Y (Author), Moreno-Macías, H. (Author), Morrison, A.C (Author), Muzny, D.M (Author), Natarajan, P. (Author), Nelson, S.C (Author), NHLBI TOPMed Lipids Working Group (Author), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium (Author), Nilsson, P.M (Author), O'Connell, J.R (Author), Orho-Melander, M. (Author), Orozco, L. (Author), Palmer, C.N.A (Author), Palmer, N.D (Author), Park, C.J (Author), Park, J. (Author), Park, K.S (Author), Pedersen, O. (Author), Peloso, G.M (Author), Peralta, J.M (Author), Peyser, P.A (Author), Post, W.S (Author), Preuss, M. (Author), Psaty, B.M (Author), Qi, Q. (Author), Rader, D.J (Author), Rao, D.C (Author), Redline, S. (Author), Reiner, A.P (Author), Revilla-Monsalve, C. (Author), Rich, S.S (Author), Rotter, J.I (Author), Samani, N. (Author), Schunkert, H. (Author), Schurmann, C. (Author), Selvaraj, M.S (Author), Seo, D. (Author), Seo, J.-S (Author), Sim, X. (Author), Sladek, R. (Author), Small, K.S (Author), So, W.Y (Author), Stilp, A.M (Author), Tai, E.S (Author), Tam, C.H.T (Author), Taylor, K.D (Author), Teo, Y.Y (Author), Thameem, F. (Author), Tomlinson, B. (Author), Tsai, M.Y (Author), Tuomi, T. (Author), Tuomilehto, J. (Author), Tusié-Luna, T. (Author), Udler, M.S (Author), van Dam, R.M (Author), Vasan, R.S (Author), Viaud Martinez, K.A (Author), Wang, F.F (Author), Wang, M. (Author), Wang, X. (Author), Watkins, H. (Author), Weeks, D.E (Author), Willer, C.J (Author), Wilson, J.G (Author), Witte, D.R (Author), Wong, T.-Y (Author), Yanek, L.R (Author), Zhang, D. (Author)
Format: Article
Language:English
Published: Cell Press 2022
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