Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model

Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model

Purpose: There is a great need to reduce the toxicity of chemotherapy used in the management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional pressurized delivery of oxaliplatin can minimize peripheral neuropathy in mice. Methods: We used an orthotopic PDAC mouse model and del...

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Bibliographic Details
Main Authors: Cox, B. (Author), Erdem, S. (Author), Frizzi, K. (Author), Jaroch, D. (Author), Katz, S. (Author), Ray, P. (Author), Shankara Narayanan, J.S.N (Author), Vicente, D. (Author), White, R. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media B.V. 2022
Subjects:
animal experiment
animal model
animal tissue
Article
C57BL 6 mouse
cancer control
cervical spine dislocation
hepatic portal vein
histopathology
immunohistochemistry
inductively coupled plasma mass spectrometry
male
maximum tolerated dose
mouse
nerve conduction velocity
nonhuman
oxaliplatin
oxaliplatin-induced peripheral neuropathy
pancreatic ductal carcinoma
pancreatic ductal carcinoma cell line
tumor growth
tumor volume
tumor weight
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