Long-term low dose nitisinone therapy in adults with alkaptonuria shows no cognitive decline or increased severity of depression

Long-term low dose nitisinone therapy in adults with alkaptonuria shows no cognitive decline or increased severity of depression

Little is documented on whether nitisinone-induced hypertyrosinaemia alters cognitive functioning or leads to worsening depression in alkaptonuria (AKU). Wechsler Adult Intelligence Scale-IV (WAIS-IV) and Beck Depression Inventory-II (BDI-II) assessments were performed before and annually following...

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Bibliographic Details
Main Authors: Clarke, P. (Author), Davison, A.S (Author), Griffin, R. (Author), Harrold, J.A (Author), Hughes, G. (Author), Ranganath, L.R (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
adult
aged
alkaptonuria
Alkaptonuria
antidepressant agent
Article
BDI-II
Beck Depression Inventory
cognition
cognitive functioning
controlled study
depression
dietary intake
disease exacerbation
female
human
intelligence quotient
liquid chromatography-mass spectrometry
long term care
longitudinal study
low drug dose
major clinical study
male
nitisinone
perception
processing speed
retrospective study
tyrosine
tyrosinemia
WAIS-IV
Wechsler adult intelligence scale
working memory
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