Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles

Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes. Dendrogenin A (DDA) is an endogenous tumour suppressor cholesterol-derived metabolite. It is a new class of li...

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Bibliographic Details
Main Authors: Attia, M. (Author), Ayadi, S. (Author), Bourgailh, F. (Author), Bunay, J. (Author), Carayon, K. (Author), de Medina, P. (Author), Lamazière, A. (Author), Lotteau, V. (Author), Payré, B. (Author), Perrin-Cocon, L. (Author), Poirot, M. (Author), Pucheu, L. (Author), Record, M. (Author), Silvente-Poirot, S. (Author), Soulès, R. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
5-hydroxy-6-(2-(1H-imidazol-4-yl)ethylamino)cholestan-3-ol
animal
Animals
bis(monoacylglycero)phosphate
cancer
cholestanol
Cholestanols
cholesterol
Cholesterol
dendrogenin A
differentiation
exosome
exosomes
Exosomes
imidazole derivative
Imidazoles
liver X receptor
Liver X Receptors
Lysobisphosphatidic acid
metabolism
Mice
mouse
neoplasm
Neoplasms
nuclear receptor
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