Effect of JAK Inhibition on the Induction of Proinflammatory HLA–DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon-γ

Effect of JAK Inhibition on the Induction of Proinflammatory HLA–DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon-γ

Objective: Findings from recent transcriptome analyses of the synovium of patients with rheumatoid arthritis (RA) have revealed that 15-fold expanded HLA–DR+CD90+ synovial fibroblasts potentially act as key mediators of inflammation. The reasons for the expansion of HLA–DR+CD90+ synovial fibroblasts...

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Bibliographic Details
Main Authors: Andreeva, I. (Author), Chen, H. (Author), Grieshaber-Bouyer, R. (Author), Kolb, P. (Author), Lorenz, H.-M (Author), Merkt, W. (Author), Rao, D.A (Author), Tretter, T. (Author), Tykocinski, L.-O (Author), Wabnitz, G. (Author), Watzl, C. (Author), Zhao, S. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
Arthritis, Rheumatoid
drug effect
fibroblast
Fibroblasts
gamma interferon
HLA DR antigen
HLA-DR Antigens
human
Humans
Interferon-gamma
metabolism
pathology
rheumatoid arthritis
synovial fluid
Synovial Fluid
Synovial Membrane
synovium
Thy 1 membrane glycoprotein
Thy-1 Antigens
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